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Bhatt, Shailendra
- Solubility Enhancement of Nebivolol by Solid Dispersion Technique
Abstract Views :202 |
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Authors
Affiliations
1 Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, 302020, IN
1 Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, 302020, IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 3 (2014), Pagination: 134-140Abstract
Aim of the present study is to improve solubility of nebivolol by different technological approaches during the pharmaceutical product development. Solid dispersion technique using wide variety of carriers such as PEG 6000 and PVP K30 were prepared in ratio 1:1, 1:3 and 1:5 by fusion and solvent evaporation method. All the solid dispersions were evaluated for drug content, phase solubility, in vitro dissolution study. Solubility of PEG 6000 and PVP K30 indicates a linear relationship (AL type of curve) in the investigated polymer concentration range. The Gibb's free energy showed declined trend with increase in the carrier concentrations. Different drug-carrier concentration level fitted to different kinetic model and it was found that solid dispersions exhibited fickian diffusional characteristics and best fitted to Higuchi model. A PVP K30 solid dispersion (1:5 ratio) prepared by solvent evaporation method showed faster dissolution rate (93.31 %) in 30 min among studied solid dispersions. The overall results showed that process of nebivolol transfer from water to carrier solution is more favorable at higher level of PVP K30. The solid dispersion of drug: PVP K 30 (1:5 ratio) prepared by solvent evaporation method was found to be optimum in term of solubility and dissolution rate. Hence, we can concluded that solubility of nebivolol can be enhanced using this carrier ratio.Keywords
Nebivolol, Solid Dispersion, Fusion Method, Solvent Evaporation Method, PEG 6000, PVP K30.- Fast Dissolving Tablet: Convenient Dosage Form for Patients
Abstract Views :184 |
PDF Views:0
Authors
Affiliations
1 K.B. Institute of Pharmaceutical Education and Research, Gandhi nagar. (Gujarat), IN
2 Sardar Patel College of Pharmacy, Bakrol, Anand. (Gujarat), IN
1 K.B. Institute of Pharmaceutical Education and Research, Gandhi nagar. (Gujarat), IN
2 Sardar Patel College of Pharmacy, Bakrol, Anand. (Gujarat), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 71-79Abstract
Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity, along with excipients, evaluation test, marketed formulation, and drugs explored in this field.Keywords
Disintegrants, Fastdissolving Tablets, Superdisintegrants.- Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using UV Spectrophotometric Method
Abstract Views :178 |
PDF Views:0
Authors
Chinmoy Kumar
1,
Manish Kumar
1,
Vipin Saini
2,
Shailendra Bhatt
1,
A. Pandurangan
1,
Anuj Malik
1,
Preeti Pal
1,
Laxmi Narayan Shetty
3
Affiliations
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2742-2747Abstract
The combination tablets dosage form of Telmisartan and Nebivolol hydrochloride dissolution method was developed by UV spectrophotometer and validated was according to the ICH guidelines. The any official method of this combination drugs was not available. In this proposed method two commercial brands of drug was used. The simultaneous estimation of Telmisartan and Nebivolol hydrochloride was performed in this proposed method which includes to solving of simultaneous equation. The wavelength of Telmisartan 296nm and 281nm of Nebivolol hydrochloride was used in this simultaneous equation. The dissolution mediums such as 0.1N HCl, phosphate buffer, SFG (without enzyme) at various ph was used in this method. The selected proposed dissolution method was SFG dissolution media (without enzyme) 900 ml, speed 75 rpm, USP type II apparatus and temperature at 37 ± 0.5°C and drug release than 85% within 45mints. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan and Nebivolol hydrochloride pharmaceutical combine tablets dosage form.Keywords
Telmisartan, Nebivolol Hydrochloride, Simultaneous Equation, Dissolution, Validation, ICH Guidelines.References
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- Uv-visible Spectrophotometric Method Development and Validation for the Estimation of Curcumin and Tetrahydrocurcumin
Abstract Views :71 |
PDF Views:0
Authors
Affiliations
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 650-654Abstract
Background: Curcumin shows degradation in the solution of high pH. There is a need for development of a method which can estimate the drug release precisely and accurately. The UV spectroscopy due to its simplicity and specificity is the most popular for method development for the determination of drugs. Objective: The present study was aimed to develop the UV-Visible spectrophotometric method for the assessment of curcumin and tetrahydrocurcumin (THC) using a stable solvent system. Method: The solubility of curcumin and tetrahydrocurcumin was determined at various physiological pH levels. Non-ionic surfactant, tween 80 was used with selected media to avoid the degradation of drugs. The selected solvent system was further validated according to guidelines of the international conference on harmonization (ICH) and the analytical parameters like linearity, veracity, sensitivity and accuracy were studied. Results: The solvent systems Phosphate buffer of pH 6.8+2% tween 80 and Phosphate buffer of pH 6.8+1% tween 80 were found optimum for estimation of curcumin and THC respectively. All the validation parameters were found within the range for developed methods. Conclusion: The proposed method is very simple and can be used for routine quality control testing of curcumin and tetrahydrocurcumin.Keywords
Curcumin, Tetrahydrocurcumin, Phosphate buffer pH 6.8, Tween 80, UV-Visible spectrophotometric method development.References
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